A destructive storm system that has already spawned at least 10 reports of tornadoes and killed multiple people in Missouri now threatens 80 million Americans with dangerous weather Wednesday.

The storm system is trekking east across the central US after battering parts of Missouri, Iowa, Illinois and Michigan.

Multiple deaths and injuries have been reported after a possible tornado struck Bollinger County, Missouri, Highway Patrol Sgt. Clark Parrott told CNN.

The exact number of casualties is not clear because reports are still coming in, Parrott said Wednesday morning.

“This is an active search and rescue event,” he said.

Resources from all across southeast Missouri are assisting local officials, Parrott said.

A new tornado watch was issued for parts of northern Indiana, southern Michigan and northwest Ohio until 4 p.m. ET Wednesday, the Storm Prediction Center said.

The watch covers more than 10 million people and includes the cities of Detroit and Grand Rapids, Michigan, as well as South Bend and Fort Wayne, Indiana.

Potential threats include damaging winds, large hail and possible tornadoes.

At least nine tornadoes were reported Tuesday, including two in Iowa and seven in Illinois, where several buildings were damaged in the town of Colona and multiple semi-trucks blown over along the I-88.

Softball-sized hail ‘sounded like bricks hitting the roof’

The most notable impact has been large, baseball-sized hail. There were over 100 hail reports mainly across Iowa, Illinois, Missouri and Michigan Tuesday. Davenport, Iowa, was pelted with 4-inch hail – just larger than a softball – while Oswego received smaller, baseball-sized hail.

“Worst hail I’ve ever heard in Davenport. Sounded like bricks hitting the roof,” Davenport resident Paul Schmidt wrote on Facebook.

A tornado warning was issued early Wednesday near Hardy, Arkansas, where the weather service reported the storm had produced “a large and extremely dangerous tornado.” Hardy is about 60 miles northwest of Jonesboro, Arkansas.

“It’s tough to think of the possibility of another round of severe weather in the midst of this recovery, but we must remain vigilant and prepared,” Little Rock Mayor Frank Scott, Jr. said in a statement. “Especially, in our already hard-hit neighborhoods, please have a plan in place to stay save, and avoid staying overnight in damaged structures.”

A separate tornado watch was issued for portions of eastern Oklahoma, western Arkansas, and northeastern Texas until noon, the Storm Prediction Center said. The watch includes Fayetteville and Fort Smith in Arkansas, and Texarkana, Texas.

“Thunderstorms forming along and ahead of two merging cold fronts will pose a threat for all severe hazards: wind, hail and tornado,” the storm center said.

An enhanced risk of severe storms, level 3 of 5, is forecast from northeastern Arkansas to northern Ohio and central Michigan, stretching from Detroit to Memphis, where residents may need to brace for strong tornadoes, damaging wind gusts and large hail.

The greatest threat will be over the Great Lakes region, including Chicago, Detroit and Indianapolis, where strong tornadoes are possible from late morning into the early evening hours.

“Weather conditions in these areas could be life-threatening at times, and those in affected areas should pay close attention to the local NWS Weather Forecast Office for Advisories, Watches, and Warnings,” the weather service warned.

Excessive rainfall totals of 1-3 inches are also possible from eastern Texas to southern Ohio.

Blizzard conditions engulf parts of the Northern Plains

Even as twisters threaten the Midwest and South, winter storms are expected to plague the Northern Plains. The region is forecast to be hit by a blizzard Wednesday, a day after “blizzard conditions” led to the shutdown of more than 100 miles of Interstate 90.

Widespread heavy snow totals are expected from the northern Rockies to the northern Plains.

“Some April snowfall records will be challenged in the Dakotas and northwest Minnesota, and the highest totals may locally exceed two feet,” the National Weather Service said.

Heavy snow and strong winds will also combine to create widespread blizzard conditions with near zero visibility, making travel dangerous to impossible.

“Cold temperatures will feel even colder due to the strong winds, and life-threatening wind chills below zero are forecast in the northern Plains,” the National Weather Service said.

The North Dakota Department of Transportation urged drivers to stay off the roads, warning that conditions are too dangerous even for emergency crews.

“If you don’t need to drive, stay off the roads. It’s dangerous for you and emergency crews. If you’re stranded, crews may not be able to reach you,” the transportation department tweeted.